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Journal: Frontiers in Neuroscience
Article Title: Monoclonal Antibodies From Anti-NMDA Receptor Encephalitis Patient as a Tool to Study Autoimmune Seizures
doi: 10.3389/fnins.2021.710650
Figure Lengend Snippet: Administration of 5F5, 2G6, or 3C11 monoclonal anti-N-methyl-D-aspartate receptor (NMDAR) antibodies precipitated seizures in mice. (A) Seizure burden was similar in 5F5 ( n = 15, red circles), 2G6 ( n = 12, blue circles) and 3C11 ( n = 12, green circles) antibody-treated groups. Data are median total seizure counts in 2 weeks. ** p < 0.01, ANOVA with Dunnett’s multiple comparisons tests; open cycles, 1X antibodies; filled cycles, 10X antibodies. (B) The distribution of cumulative seizure counts in all anti-NMDAR antibody-treated groups. *** p < 0.001, t -test. (C) Time to the first seizure was not different between the four treatment groups ( p = 0.39, Kruskal-Wallis test). Data are median latencies. Note log scale on Y axis.
Article Snippet: Seizure burden, locomotor activity, and anxiety scores in each treatment group were expressed as median total seizure counts over 2-weeks of infusion, total distance traveled and percent time spent in the center, respectively and the groups were compared using the one-way analysis of
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